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KMID : 0545120120220111478
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 11 p.1478 ~ p.1481
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New Geldanamycin Analogs from Streptomyces hygroscopicus
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Cheng-Zhu Wu
Jang Jae-Hyuk
Ahn Jong-Seog
Hong Young-Soo
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Abstract
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Geldanamycin (GM) and its analogs are important anticancer agents that inhibit heat shock protein (Hsp) 90, which is a major chaperone protein in cancer cells. Accordingly, based on interest in obtaining novel natural GM derivatives, the potential of Streptomyces hygroscopicus JCM4427, a GM producer, was explored for novel natural GM derivative(s), resulting in the discovery of new GM analogs as a biosynthetic shunt product and intermediates from its fermentation broth. In this study, the fermentation, isolation, structure determination, and biological activity of the compounds, two new tetracyclic thiazinogeldanamycin (1) and 19-hydroxy-4,5-dihydrogeldanamycin (3), together with the three known 4,5-dihydrothiazinogeldanamycin (2), reblastatin (4), and 17-demethoxy-reblastatin (5), are described.
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KEYWORD
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Geldanamycin, Biosynthetic shunt product, Natural products
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